Our Leadership Team

Octave’s team consists of highly experienced healthcare founders, high-level investors and first-in-class collaborators. 


CEO, Founder

Entrepreneur. Visionary. Passionate.

Bill has more than 25 years of start-up experience in a broad range of medical specialties intersecting science, technology, clinical medicine, and business strategy. Prior to founding Octave Bioscience, he served as the CEO of Crescendo Bioscience which created novel measurement tools and software in the field of rheumatology. Prior to this, he was the President of Alpha BioPartners, a strategic consulting firm advising the launch of new life sciences companies. While at Alpha BioPartners, Bill created the business plan for Crescendo and co-founded Altheus Therapeutics and Biolytx Pharmaceuticals. Prior to that, he served as the initial CEO of Selexys Pharmaceuticals and interim CEO of Inoveon in ophthalmology. In the 1990s, Bill was Chairman and CEO of UroCor, a urology specialty diagnostics company which he scaled from start-up through IPO. Earlier in his career, he was Vice President of Baxter International’s $1.0 billion Scientific Products Division and held management positions at the American Hospital Supply and Becton Dickinson. He currently serves on the board of directors for CareDx, Navican, Genalyte and CoFactor. Previously he was on the board of Prometheus Laboratories. Bill holds a BS in Business Management from Bob Jones University.


COO, Co-Founder

Leader. Builder. Problem Solver.

Melinda has over two decades of experience starting and leading health companies. Using her expertise, she wraps a company around a technical/scientific team so they can focus on meeting the company’s milestones. Melinda built CardioDx, a molecular diagnostics company specializing in cardiovascular genomics, and ParAllele, a high-throughput sequencing and SNP discovery company from the foundation point. ParAllele was acquired by Affymetrix in what one investor said was their best investment of the decade. Previously, she served as the Inaugural Entrepreneur in Residence for New York City, solving problems for aspiring entrepreneurs, and as Chair of the Board for the Save the Redwoods League. Prior to ParAllele, she guided Molecular Dynamics Manufacturing, building it from an 8 person to 85 person manufacturing organization. Melinda holds an MBA from Harvard and a BS from UC Berkeley.



Innovator. Data driven. Purposeful.

Erwan has over two decades experience in both start-ups and global corporations across multiple industries: high tech, industrials, and digital health. Prior to Octave Bioscience, he was global head of software engineering for the medical device group at EMD Serono, in Switzerland, integrating health in people’s digital life for the chronic diseases, growth hormones, and consumer divisions. Prior to this, he led a 300 engineers research and development team for building control systems at Honeywell, developing global digital IoT platforms for home automation and commercial buildings. Prior to that, he led teams at high tech start-ups, Cisco and Logitech. Erwan credits his time at Cisco as being the most formative for developing his leadership, strategic and program skills. He led a firewall release with projected revenues of $1.5B, delivered on time and within budget. Erwan holds a Global Executive MBA from TRIUM, a joint degree between NYU Stern, London School of Economics and HEC Paris. He also holds a Master of Science in Mechanical Engineering (Diplome d’Ingenieur) from Sup’Meca, Saint-Ouen, France.

Maital Shemesh-Rasmussen

Chief Commercial Officer

Imaginative. Trailblazer. Connector.

Maital is a leader in global digital health marketing strategy with extensive experience in the growth and commercialization of patient-centric, data-driven personalized care  products and value-based approaches. Maital comes to Octave from Roche (DIS), where she served as Global Head of Solution Marketing. In this role, she defined Roche’s new health tech strategy, bringing to market advanced digital solutions and commercial models that positioned Roche as a world leader in health technology. Some of her other previous positions include Director of Strategic and Product Marketing at Oracle Healthcare and Precision Medicine, Vice President of Global Marketing at JPMorgan Chase Bank, and Founder and CEO of Rasmussen Communications. She is also on the Board of Directors at Pluristem Therapeutics. Maital studied Behavioral Sciences at Ben Gurion University, Marketing Communication and Political Science at Bar-Ilan University, and Strategy, Finance, and Computer Science at Columbia University.

Mike Edgeworth, MD

Chief Population Health Officer

Collaborator. Pathfinder. Value-driven.

Mike has over two decades of experience as a neurologist and physician leader and is dedicated to data-driven problem solving, value-based health care and improving clinical outcomes for patient populations through collaborative relationships. Prior to Octave, he was a Senior Medical Executive with Cigna Medicare where he was responsible for medical trend and affordability, clinical program innovation, value-based partnerships and development of quality networks. Mike credits his time at Cigna, including completion of Cigna’s Physician Leadership Development Program, with cultivating competencies in healthcare innovation, business acumen and collaborative management skills. Prior to Cigna, Mike provided compassionate care for patients with chronic neurodegenerative diseases and acute neurological conditions and served as Chairman of Medicine at StoneCrest Medical Center. Prior to StoneCrest, Mike completed his neurology training and neuro-oncology fellowship and served as Assistant Professor at Vanderbilt University Medical Center in the Division of Neuro-Oncology. While at Vanderbilt, he obtained a Master of Science in Clinical Investigation.  Mike resides in Nashville, TN, and is originally from Mississippi, where he obtained an undergraduate degree in Chemistry from Mississippi State University and Doctor of Medicine from the University of Mississippi.

Our Board of Directors


Octave Bioscience


Kleiner Perkins Caufield & Byers


Independent Venture Capital & Private Equity Professional


Managing Director, Healthcare, Sandbox Industries


CEO, Vir Biotechnology


Foundation Medicine, Section 32


Northpond Ventures

Our Investors

BlueCross BlueShield Venture Partners, L.P.
echo Health Ventures
Northpond Ventures
Deerfield Advancing Healthcare


You want to be mission driven, use the latest technologies to solve big problems, and work with passionate people. So do we!